Detalhe da pesquisa
1.
Crystal structure of the Mycobacterium tuberculosis VirS regulator reveals its interaction with the lead compound SMARt751.
J Struct Biol
; 216(2): 108090, 2024 Mar 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-38548139
2.
Loss-of-function mutations in ndh do not confer delamanid, ethionamide, isoniazid, or pretomanid resistance in Mycobacterium tuberculosis.
Antimicrob Agents Chemother
; 68(1): e0109623, 2024 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38038476
3.
ArfGAP1 restricts Mycobacterium tuberculosis entry by controlling the actin cytoskeleton.
EMBO Rep
; 19(1): 29-42, 2018 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-29141986
4.
A novel codrug made of the combination of ethionamide and its potentiating booster: synthesis, self-assembly into nanoparticles and antimycobacterial evaluation.
Org Biomol Chem
; 17(20): 5129-5137, 2019 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-31073555
5.
Structural analysis of the interaction between spiroisoxazoline SMARt-420 and the Mycobacterium tuberculosis repressor EthR2.
Biochem Biophys Res Commun
; 487(2): 403-408, 2017 05 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-28416386
6.
Phenotypic assays for Mycobacterium tuberculosis infection.
Cytometry A
; 91(10): 983-994, 2017 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-28544095
7.
New active leads for tuberculosis booster drugs by structure-based drug discovery.
Org Biomol Chem
; 15(48): 10245-10255, 2017 Dec 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-29182187
8.
Effects of Lipid-Lowering Drugs on Vancomycin Susceptibility of Mycobacteria.
Antimicrob Agents Chemother
; 60(10): 6193-9, 2016 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-27503643
9.
A fragment merging approach towards the development of small molecule inhibitors of Mycobacterium tuberculosis EthR for use as ethionamide boosters.
Org Biomol Chem
; 14(7): 2318-26, 2016 Feb 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-26806381
10.
Mechanism of competence activation by the ComRS signalling system in streptococci.
Mol Microbiol
; 87(6): 1113-32, 2013 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-23323845
11.
The Mycobacterium tuberculosis transcriptional repressor EthR is negatively regulated by Serine/Threonine phosphorylation.
Biochem Biophys Res Commun
; 446(4): 1132-8, 2014 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-24667600
12.
Unconventional surface plasmon resonance signals reveal quantitative inhibition of transcriptional repressor EthR by synthetic ligands.
Anal Biochem
; 452: 54-66, 2014 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-24561027
13.
Structural activation of the transcriptional repressor EthR from Mycobacterium tuberculosis by single amino acid change mimicking natural and synthetic ligands.
Nucleic Acids Res
; 40(7): 3018-30, 2012 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-22156370
14.
Optimizing the use of current antituberculosis drugs to overcome drug resistance in Mycobacterium tuberculosis.
Infect Dis Now
; 54(1): 104807, 2024 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-37839674
15.
Discovery of dual-active ethionamide boosters inhibiting the Mycobacterium tuberculosis ESX-1 secretion system.
Cell Chem Biol
; 31(4): 699-711.e6, 2024 Apr 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-38181799
16.
Both Nitro Groups Are Essential for High Antitubercular Activity of 3,5-Dinitrobenzylsulfanyl Tetrazoles and 1,3,4-Oxadiazoles through the Deazaflavin-Dependent Nitroreductase Activation Pathway.
J Med Chem
; 67(1): 81-109, 2024 Jan 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-38157261
17.
Structural and docking studies of potent ethionamide boosters.
Acta Crystallogr C
; 69(Pt 11): 1243-50, 2013 Nov.
Artigo
em Inglês
| MEDLINE | ID: mdl-24192167
18.
Exploring the Antitubercular Activity of Anthranilic Acid Derivatives: From MabA (FabG1) Inhibition to Intrabacterial Acidification.
Pharmaceuticals (Basel)
; 16(3)2023 Feb 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-36986435
19.
On the Hunt for Next-Generation Antimicrobial Agents: An Online Symposium Organized Jointly by the French Society for Medicinal Chemistry (Société de Chimie Thérapeutique) and the French Microbiology Society (Société Française de Microbiologie) on 9-10 December 2021.
Pharmaceuticals (Basel)
; 15(4)2022 Mar 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-35455385
20.
The small-molecule SMARt751 reverses Mycobacterium tuberculosis resistance to ethionamide in acute and chronic mouse models of tuberculosis.
Sci Transl Med
; 14(643): eaaz6280, 2022 05 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35507672